The Tree of Knowledge
Maturana, H. R. and Varela, F. J. The Tree of Knowledge: The Biological Roots of Human Understanding.
Another attempt to think big, and studiously avoid falling into the confusion of the perceived world and what I term the R-world. As here, their views have serious moral and ethical consequences.
Sample P-world-y quote:
We who are flesh-and-blood people are no strangers to the world in which we live and which we bring forth through our living. (p. 129)